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Marburg GmbH
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Primary Cell Co Ltd
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PELOBIOTECH GmbH
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Image Search Results
Journal: Virus Research
Article Title: Transcriptomics of Marburg virus-infected primary proximal tubular cells reveals negative correlation of immune response and energy metabolism
doi: 10.1016/j.virusres.2024.199337
Figure Lengend Snippet: MARV infection of primary human proximal tubular cells (PTC). (A) MARV copies (by kallisto) at 20 h and 40 h post infection (p.i.). Mock: three uninfected PTC replicates from 40 h p.i. (B) Bright field image of mock and MARV infected PTC at 40 h p.i. taken with 10x objective at a NIKON TS-100 microscope. ( C) Principial component analysis of mock-infected, 20 h- and 40 h MARV-infected PTC, demonstrating a transcriptome difference at 20 h- and especially at 40 h p.i. (D) MARV transcriptomics at 40 h p.i.: MA plot, depicting significantly ( q <0.05) up-regulated transcripts in red and down-regulated ones in blue (cut-off fold-change ≥2). (E) Heatmap of gene expression changes after MARV infection, again demonstrating transcriptome differences at 20 h- and especially at 40 h p.i. (replicates: 1–3: mock; 4–6: 20 h p.i. and 7–9: 40 h p.i. The heatmap is color coded: blue represents down- and red upregulated genes).
Article Snippet: •
Techniques: Infection, Microscopy, Gene Expression